Capabilities - FAQ



What we do

We evaluate the pharmacodynamic efficacy potential of investigational compounds targeting brain diseases using translational EEG Biomarkers in vivo in freely-moving animal models.

01 Organization

SynapCell is a CNS-expert biotechnology company with more than 15 years of experience in the field of Central Nervous System disorders. As a true partner of the biopharmaceutical industry, we identify and qualify the therapeutic potential of our clients’ lead candidates in Epileptic disorders, Parkinson’s disease, Psychiatric or Neurodegenerative disorders. In other words, SynapCell tests for you the efficacy of your compound.
At SynapCell, we do care about environmental footprint. Our permises are located inside a new energy-efficient building at the heart of the French Silicon Valley, close to Grenoble.

All tests are performed using EEG in vivo, in freely-moving and clinically-relevant rodent models of brain diseases.

Our EEG Biomarker approach enables to objectively appreciate the pharmacodynamic efficacy potential of compounds tested using resting state EEG, Event related (ERP, ASSR) or pharmaco-induced EEG Biomarkers.

Our EEG-based Cue® platform is the smart combination of a team of skilled neuroscientists, clinically-relevant rodent models, high-end recording techniques and proprietary signal processing.

Our pharmacodynamic assays use the robustness and translational power of EEG for:

  • Lead selection (screening of small libraries of compounds)
  • Lead validation (dose-response effect, pharmacodynamic effectkinetics)
  • Disease modifying or neuroprotective potential
  • Anti-epileptogenic, anti-epileptic effect using non-convulsive animal models.
  • Model phenotyping,
  • EEG Biomarker development and identification,
  • Program De-risking (pro-epileptic, seizure aggravting effect)
  • Dose optimizing, dose ranging.
  • Acute or chronic protocols
  • Clinical-like, crossover designs
  • Exploratory EEG program, designed as a place were you can shape your experiment from A to Z.

We are a fully integrated company, with our own animal and research facilities. As a French organization, the animal facility is certified by the French Ministry of Research and the Veterinarian Service. As of 2017, the facility covers as much as 4310 square feet, and has a capacity of over 400 animals. Access to the platform is restricted to authorized personal exclusively with high-level of security. See Quality &Animal Welfare section for more details.
We do apply the Three R’s sustainability rule (Replacement, Reduction, Refinement) in the way we conduct our activities. In addition, all protocols are submitted to and approved by the Ethic Committee. To support both internal and external R&D programs for our clients, we have developed three cutting-edge platforms in-house for Neurosurgery, EEG/ERP recording and advanced Signal analysis. Everything is therefore performed internally for optimum project efficiency, tracking, quality management and cost optimization.

Keeping close contact with the Sponsor is key for both parties to get aligned on all milestones and deliverables of the study. This is done for each client from project initiation to completion, at every individual step. Your main contacts will be with our Business Development team for commercial and legal steps, our Head of Science for protocol and study design and with the Head of Operations for project coordination and study report.

weeks to result*
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Labs we own
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in vivo, freely-moving
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Satisfied customers
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Compounds tested

*for a 12 compounds epilepsy screening on n=4 MTLE mice

02 Project Management

Once commercial and legal steps are completed, and agreement has been made between SynapCell and the Sponsor on the study details, the project is ready for launch. Depending on the nature of the study, this step can take 2 to 3 weeks on average if a planning slot is available.

On average, between 3 to 6 weeks from study launch for first data and from 11 to 15 weeks for the final report if Sponsor compound is received on schedule. For example, a full dose-response assessment of an anti-epileptic compound on the SynapCell MTLE mouse takes 7 weeks to generate the model (Epileptogenesis phase) and 4 to 5 additional weeks to generate the results.

We are committed to providing the Sponsor with proactive feedback all along the study course. The Head of Operations maintains continuous contact with the Sponsor to organize logistics related to compound shipment for example or any necessary information for successful project management. At each important milestone of a study, a meeting with the Sponsor is arranged, to provide an update on the most recent results.

We do not conduct Toxicity nor Safety Studies litterally speaking. We are focusing our offer on preclinical efficacy studies that are performed exclusively in vivo on freely-moving animal models. However, the GAERS model can be used as a derisking model to identify seizure-aggravationg or pro-epileptic effect of any compound. SWD therefore could be used as a safety biomarker. In addition,, we pay a particular attention to animal welfare all along the study course. In the event of potential toxic effect observed, we immediately warn the Sponsor for action. 

03 Quality assurance & Animal welfare

The process involved in managing studies start with a study proposal followed by a study design. All animal procedures are carried out in accordance to the guidelines of the European Community’s Council Directive 2010/63/EU on animal protection and welfare. Moreover, all processes, including animal welfare and experimental procedures, are documented in our Quality Management System.

All the staff members involved in the study hold the authorization to perform animal experimentation and have several years of experience in neurosciences, pharmacology, surgery, signal recording or processing. Half of our team holds a PhD, and all SynapCell experimenters are involved in a continuous training program certified by the French Ministry of Agriculture. Training programs could be either internal or external.

All studies are performed following SynapCell local Standard Operating Procedures (SOP) and are inspired from the OCDE rule of Good Laboratory Practices [C(97)186/Final]. Even if preclinical efficacy studies are not required to be GLP compliant, SynapCell is aligfned with the OCDE principles of GLP and applies its rules.

SynapCell IT security consists in protecting the company’s computer systems from the theft or damage to its hardware, software or information, as well as from disruption or misdirection of the services provided. Security measures taken include controlling physical access to the hardware, as well as protecting against harm that may come via network access, data and code injection. Therefore, Sponsor information is managed by 3 levels of security:
  • Physical security: there is a restricted access to the building for everyone, it needs a magnetic badge detained by SynapCell employee
  • Daily Backup: workstations are backed up to server once a day and additional backup run every night through Internet on a dedicated remote server
  • Access-Information: Incident or failure will be automatically fixed through a SPARE drive automatic take over system.
In addition, all team members involved with the Sponsor’s project are committed to full confidentiality. To find out more on our capabilities and how we can collaborate, please contact us


Monitoring the Pharmacodynamic effect of your compound in vivo

  • Electroencephalographic (EEG) and Local Field Potentials (LFP) recordings of brain activity changes.
  • Telemetric or tethered activity recordings in vivo, exclusively in freely-moving rodents (Rats and mice).
  • Surface (cortical) or depth electrodes implantation.
  • Any brain structure at reach.

Objective and robust readouts

Data generated by our EEG platform feature dedicated expert analysis and personalized reporting.

  • Resting state EEG (RS oscillatory activities)
  • Evoked oscillatory activities, Event related EEG Biomarkers (ASSR, ERP, evoked power
  • Pharmaco-induced oscillatory activities and models.
  • Simultaneous multisite recordings.
  • Multisite coherence
  • Inter-trial coherence (ITC)
  • Spectral analysis and recommendations
  • Power changes
  • Phase-Amplitude Coupling
  • Sleep trend analysis on demand
  • Video monitoring on demand
  • Abnormal Involuntary Movements (AIM) scoring in LID context
  • Model Phenotyping
  • EEG Biomarker identification

Bridging the Preclinical to Clinical gap

  • Clinical-like protocols, blinded, crossover designs.
  • Acute or chronic paradigms.
  • Longitudinal studies.
  • Customizable protocols including number of animals per group or pharmacological exposure.
  •  Pharmaco-EEG profiling of a compound to determine its effects on resting EEG activities or on evoked or drug-induced EEG activities.
  • Blood/plasma sampling and shipping.

or Customized services.


Dose Optomizing


Which dose of your compound is the most effective, and when is the peak effect? 

Dose-response protocols can be carried out longitudinally, in vivo, in a dynamic fashion.

Chronic or acute paradigms possible as well as reversion challenges. 


Lead Validation and Selection


Select then Validate your most effective drug compounds after a screening protocol.

Candidates with best potential in lowering pathological EEG signatures (biomarkers) will be selected to go through dose-response protocols, then optimal dose identified.


Biomarker testing


EEG Biomarkers offer high translation power, are robust and objective.

Let's find together the new EEG Biomarker in the model of your choice and mark your footprint in the history of Science?




Select compounds with best therapeutic potential using the power of translational EEG Biomarkers.

Our EEG screening is affordable, fast (4 weeks) and customizable.

Results clear the way for deeper characterization of the potential of drugs selected.


Head-to-Head comparison


How does your drug compare?

​Assess the best possible combination of different drugs (adjunctive therapies), demonstrate a superior effect and evaluate how your drug stands compared to reference drugs currently on the market.


Pharmacodynamic Profiling


Get further insight into pharmacological action and PK of your compound.

Characterize drug effect over time, longitudinally and demonstrate the (ir)reversibility, duration of effect or physiological turn-over of the target.


Model Phenotyping


Discover EEG biomarkers from translational models.

Our in vivo EEG platform (Cue®) offers EEG, qEEG, ERP, ASSR phenotyping to identify EEG signatures of the disease or pharmacological pathway you are working on.


Evoked Potentials


Integration and processing of sensory information is altered in several neurological and psychiatric disorders.

Auditory evoked potentials (AERP) and auditory steady state response (ASSR) can be used to assess the effect of drugs on cognitive function in vivo.

Let's talk about your next project